Connectome analysis with diffusion MRI in idiopathic Parkinson's disease: Evaluation using multi-shell, multi-tissue, constrained spherical deconvolution

K Kamagata; A Zalesky; T Hatano; MA Di Biase; O El Samad; S Saiki; K Shimoji; KK Kumamaru; K Kamiya; M Hori; N Hattori; S Aoki; C Pantelis

Journal article

Connectome analysis with diffusion MRI in idiopathic Parkinson's disease: Evaluation using multi-shell, multi-tissue, constrained spherical deconvolution

K Kamagata, A Zalesky, T Hatano, MA Di Biase, O El Samad, S Saiki, K Shimoji, KK Kumamaru, K Kamiya, M Hori, N Hattori, S Aoki, C Pantelis

Neuroimage Clinical | ELSEVIER SCI LTD | Published : 2018

DOI: 10.1016/j.nicl.2017.11.007

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Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disorder that affects extensive regions of the central nervous system. In this work, we evaluated the structural connectome of patients with PD, as mapped by diffusion-weighted MRI tractography and a multi-shell, multi-tissue (MSMT) constrained spherical deconvolution (CSD) method to increase the precision of tractography at tissue interfaces. The connectome was mapped with probabilistic MSMT-CSD in 21 patients with PD and in 21 age- and gender-matched controls. Mapping was also performed by deterministic single-shell, single tissue (SSST)-CSD tracking and probabilistic SSST-CSD tracking for comparison. A support vector machine was ..

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University of Melbourne Researchers

Andrew Zalesky Author

Maria Di Biase Author

Christos Pantelis Author

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Grants

Awarded by National Science Foundation

Funding Acknowledgements

This work was supported by the program for Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS) from Japan Agency for Medical Research and development (AMED); JSPS KAKENHI (JP16K19854). Christos Pantelis was supported by a National Health and Medical Research Council of Australia (NHMRC) Senior Principal Research Fellowship (ID: 1105825). Andrew Zalesky was supported by NHMRC Career Development Fellowship (GNT1047648). Maria Di Biase was supported by the Australian Rotary Health Ian Scott PhD Scholarship in Mental Health.